Intellia Therapeutics, Inc. Confidential and Anonymous Speak Up Hotline

Intellia Therapeutics, Inc. is committed to maintaining an ethical, transparent and legally compliant culture as it conducts its business and advance its mission of developing novel CRISPR/Cas9-based therapies. Accordingly, Intellia-related conduct is expected to adhere to all applicable laws, rules, and regulations, codes and policies. As part of this commitment, Intellia asks its employees and business partners to proactively ask questions and seek guidance about, and report suspected violations of, its Code of Business Conduct and Ethics or any of its other policies and procedures, or any violation or suspected violation of relevant laws, rules or regulations arising in the conduct of the Company’s business or occurring on the Company’s property.

We believe that the best way to communicate any concerns or questions you may have, or report any issues you may have observed, is to speak directly with your supervisor or management. You should also feel free to contact other members of the management team, the Chief Compliance Officer (at complianceofficer@intelliatx.com) or a member of the human resources or legal departments.

If, however, you prefer to anonymously communicate with the Chief Compliance Officer or the Audit Committee of Intellia’s Board of Directors, we ask that you use this secure website, which is hosted by a third-party provider. You do not have to provide any identifying data with your message. The provider will encrypt your message and, if you choose to leave a telephone message, anonymize your voice before forwarding it to the Chairperson of the Audit Committee and the Chief Compliance Officer.

You may leave a message using any one of two methods: Secure Web Form and Secure Hotline